Animal Models of Typical Heterotopic Ossification
نویسندگان
چکیده
Heterotopic ossification (HO) is the formation of marrow-containing bone outside of the normal skeleton. Acquired HO following traumatic events is a common and costly clinical complication. In contrast, hereditary HO is rarer, progressive, and life-threatening. Substantial effort has been directed towards understanding the mechanisms underlying HO and finding efficient treatments. However, one crucial limiting factor has been the lack of relevant animal models. This article reviews the major currently available animal models, summarizes some of the insights gained from these studies, and discusses the potential future challenges and directions in HO research.
منابع مشابه
Methodological Consideration of Various Intraosseous and Heterotopic Bone Grafts Implantation in Animal Models
Bone fracture healing is a complex process including inflammation, repair and remodeling. Bone grafts or substitute are widely accepted to treat impaired healing. Newly developed bone substitutes must undergo in vitro and in vivo testing before clinical application. All kinds of intraosseous and heterotopic implant models in small and/ or large animals are used for different bone substitutes. O...
متن کاملHeterotopic Ossification around the Knee after Internal Fixation of a Complex Tibial Plateau Fracture Combined with the Use of Demineralized Bone Matrix (DBM): A Case Report
Demineralized bone matrix has been successfully commercialized as an alternative bone graft material that not only can function as filler but also as an osteoinductive graft. Numerous studies have confirmed its beneficial use in clinical practice. Heterotopic ossification after internal fixation combined with the use of demineralized bone matrix has not been widely reported. In this paper we de...
متن کاملCharacterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification
Heterotopic ossification (HO) is the pathologic formation of bone separate from the normal skeleton. Although several models exist for studying HO, an understanding of the common in vitro properties of cells isolated from these models is lacking. We studied three separate animal models of HO including two models of trauma-induced HO and one model of genetic HO, and human HO specimens, to charac...
متن کاملProgression of Heterotopic Ossification around the Elbow after Trauma
Background: This study addresses the null hypothesis that there is no expansion of heterotopic ossification (HO) in the elbow beyond what can be seen early on. Methods: The area of HO was measured on lateral radiographs of 38 consecutive patients that had operative treatment of HO between 2000 and 2013. Measurements from radiographs obtained between 3 to 7 weeks were compared to measurements...
متن کاملAnimal models for acquired heterotopic ossification.
Heterotopic ossification (HO), the ectopic formation of bone in soft tissues, is a relevant musculoskeletal disorder that, by reduction of range of motion, may lead to significant impairment of quality of live. HO can either be acquired or hereditary. Acquired HO is seen most often after hip prosthetic surgery and pelvic trauma. In contrast, hereditary HO is commonly observed in the axial skele...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011